3-Form Flux Compactification of Salam-Sezgin Supergravity

The compactification of 6 dimensional Salam-Sezgin model in the presence of 3-form flux H is investigated. We find a torus topology for this compactification with two cusps which are the places of branes, while at the limit of large size L of the compact direction we also obtain sphere topology. This resembles the Randall-Sundrum I,II model. The branes at one of the cusps can be chosen to be 3- and 4-branes which fill our 4-dimensional space together with the fact that H=0 at this position restores the Lorentz symmetry. This compactification also provides an example for the so-called `time warp' solution, [0812.5107 [hep-th]]. According to a no-go theorem in $d\ne 6$, the time warp compactification violates the null energy condition. While the theorem is quiet for d=6, our model gives a time warp compactification which satisfies the null energy condition. We also derive the four dimensional effective Planck mass which is not obvious due to the time warp nature of the solution.Comment: 19 pages, 5 fig

Supersymmetric codimension-two branes in six-dimensional gauged supergravity

We consider the six-dimensional Salam-Sezgin supergravity in the presence of codimension-2 branes. In the case that the branes carry only tension, we provide a way to supersymmetrise them by adding appropriate localised Fayet-Iliopoulos terms and localised corrections to the Chern-Simons term and modifying accordingly the fermionic supersymmetry transformations. The resulting brane action has N=1 supersymmetry (SUSY). We find the axisymmetric vacua of the system and show that one has unwarped background solutions with "football"-shaped extra dimensions which always respect N=1 SUSY for any value of the equal brane tensions, in contrast with the non-supersymmetric brane action background. Finally, we generically find multiple zero modes of the gravitino in this background and discuss how one could obtain a single chiral zero mode present in the low energy spectrum.Comment: 21 pages, no figures, A sign error in the gauge potential at the lower brane corrected and its consequent effect discusse

Sculpting the Extra Dimensions: Inflation from Codimension-2 Brane Back-reaction

We construct an inflationary model in 6D supergravity that is based on explicit time-dependent solutions to the full higher-dimensional field equations, back-reacting to the presence of a 4D inflaton rolling on a space-filling codimension-2 source brane. Fluxes in the bulk stabilize all moduli except the `breathing' modulus (that is generically present in higher-dimensional supergravities). Back-reaction to the inflaton roll causes the 4D Einstein-frame on-brane geometry to expand, a(t) ~ t^p, as well as exciting the breathing mode and causing the two off-brane dimensions to expand, r(t) ~ t^q. The model evades the general no-go theorems precluding 4D de Sitter solutions, since adjustments to the brane-localized inflaton potential allow the power p to be dialed to be arbitrarily large, with the 4D geometry becoming de Sitter in the limit p -> infinity (in which case q = 0). Slow-roll solutions give accelerated expansion with p large but finite, and q = 1/2. Because the extra dimensions expand during inflation, the present-day 6D gravity scale can be much smaller than it was when primordial fluctuations were generated - potentially allowing TeV gravity now to be consistent with the much higher gravity scale required at horizon-exit for observable primordial gravity waves. Because p >> q, the 4 on-brane dimensions expand more quickly than the 2 off-brane ones, providing a framework for understanding why the observed four dimensions are presently so much larger than the internal two. If uplifted to a 10D framework with 4 dimensions stabilized, the 6D evolution described here could describe how two of the six extra dimensions evolve to become much larger than the others, as a consequence of the enormous expansion of the 4 large dimensions we can see.Comment: 27 pages + appendices, 2 figure

Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia

Dkk-3 is a newly characterised mortalisation-related gene and an antagonist of the Wnt oncogenic signalling pathway whose expression is decreased in a variety of cancer cell lines, suggesting that the Dkk-3 gene, located at chromosome 11p15.1, functions as a tumour suppressor gene. Although 11p15 is a ‘hot spot’ for methylation in acute lymphoblastic leukaemia (ALL), the role of Dkk-3 abnormalities has never been evaluated in this disease. We analysed CpG island methylation of the Dkk-3 promoter in six ALL cell lines and 183 ALL patients. We observed Dkk-3 hypermethylation in all cell lines and in cells from 33% (60/183) of ALL patients. Moreover, Dkk-3 methylation was associated with decreased Dkk-3 mRNA expression and this expression was restored after exposure to the demethylating agent 5-AzaC. Clinical features did not differ between hypermethylated and unmethylated patients. Estimated disease-free survival (DFS) and overall survival at 10 and 11 years, respectively, were 49.8 and 45.6% for normal patients and 10.5 and 15.1% for hypermethylated patients (P¼0.001 and 0.09). Multivariate analysis demonstrated that Dkk-3 methylation was an independent prognostic factor predicting DFS (P¼0.0009). Our data suggest that Dkk-3 methylation occurs at an early stage in ALL pathogenesis and probably influences the clinical behaviour of the disease

The large-scale structure of the halo of the Andromeda galaxy. I. Global stellar density, morphology and metallicity properties

We present an analysis of the large-scale structure of the halo of the Andromeda galaxy, based on the Pan-Andromeda Archeological Survey (PAndAS), currently the most complete map of resolved stellar populations in any galactic halo. Despite the presence

Scalar brane backgrounds in higher order curvature gravity

We investigate maximally symmetric brane world solutions with a scalar field. Five-dimensional bulk gravity is described by a general lagrangian which yields field equations containing no higher than second order derivatives. This includes the Gauss-Bonnet combination for the graviton. Stability and gravitational properties of such solutions are considered, and we particularily emphasise the modifications induced by the higher order terms. In particular it is shown that higher curvature corrections to Einstein theory can give rise to instabilities in brane world solutions. A method for analytically obtaining the general solution for such actions is outlined. Genericaly, the requirement of a finite volume element together with the absence of a naked singularity in the bulk imposes fine-tuning of the brane tension. A model with a moduli scalar field is analysed in detail and we address questions of instability and non-singular self-tuning solutions. In particular, we discuss a case with a normalisable zero mode but infinite volume element.Comment: published versio

Constraints on Dark Matter Annihilation in Clusters of Galaxies with the Fermi Large Area Telescope

Nearby clusters and groups of galaxies are potentially bright sources of high-energy gamma-ray emission resulting from the pair-annihilation of dark matter particles. However, no significant gamma-ray emission has been detected so far from clusters in the first 11 months of observations with the Fermi Large Area Telescope. We interpret this non-detection in terms of constraints on dark matter particle properties. In particular for leptonic annihilation final states and particle masses greater than ~200 GeV, gamma-ray emission from inverse Compton scattering of CMB photons is expected to dominate the dark matter annihilation signal from clusters, and our gamma-ray limits exclude large regions of the parameter space that would give a good fit to the recent anomalous Pamela and Fermi-LAT electron-positron measurements. We also present constraints on the annihilation of more standard dark matter candidates, such as the lightest neutralino of supersymmetric models. The constraints are particularly strong when including the fact that clusters are known to contain substructure at least on galaxy scales, increasing the expected gamma-ray flux by a factor of ~5 over a smooth-halo assumption. We also explore the effect of uncertainties in cluster dark matter density profiles, finding a systematic uncertainty in the constraints of roughly a factor of two, but similar overall conclusions. In this work, we focus on deriving limits on dark matter models; a more general consideration of the Fermi-LAT data on clusters and clusters as gamma-ray sources is forthcoming.Comment: accepted to JCAP, Corresponding authors: T.E. Jeltema and S. Profumo, minor revisions to be consistent with accepted versio

PAMELA/ATIC anomaly from the meta-stable extra dark matter component and the leptophilic Yukawa interaction

We present a supersymmetric model with two dark matter (DM) components explaining the galactic positron excess observed by PAMELA/HEAT and ATIC/PPB-BETS: One is the conventional (bino-like) lightest supersymmetric particle (LSP) \chi, and the other is a TeV scale meta-stable neutral singlet N_D, which is a Dirac fermion (N,N^c). In this model, N_D decays dominantly into \chi e^+e^- through an R parity preserving dimension 6 operator with the life time \tau_N\sim 10^{26} sec. We introduce a pair of vector-like superheavy SU(2) lepton doublets (L,L^c) and lepton singlets (E,E^c). The dimension 6 operator leading to the N_D decay is generated from the leptophilic Yukawa interactions by W\supset Ne^cE+Lh_dE^c+m_{3/2}l_1L^c with the dimensionless couplings of order unity, and the gauge interaction by {\cal L}\supset \sqrt{2} g'\tilde{e}^{c*}e^c\chi + h.c. The superheavy masses of the vector-like leptons (M_L, M_E\sim 10^{16} GeV) are responsible for the longevity of N_D. The low energy field spectrum in this model is just the MSSM fields and N_D. Even for the case that the portion of N_D is much smaller than that of \chi in the total DM density [{\cal O}(10^{-10}) \lesssim n_{N_D}/n_\chi], the observed positron excess can be explained by adopting relatively lighter masses of the vector-like leptons (10^{13} GeV \lesssim M_{L,E} \lesssim 10^{16} GeV). The smallness of the electron mass is also explained. This model is easily embedded in the flipped SU(5) grand unification, which is a leptophilic unified theory.Comment: 12 pages, published versio

Atmospheric effects on extensive air showers observed with the Surface Detector of the Pierre Auger Observatory

Atmospheric parameters, such as pressure (P), temperature (T) and density, affect the development of extensive air showers initiated by energetic cosmic rays. We have studied the impact of atmospheric variations on extensive air showers by means of the surface detector of the Pierre Auger Observatory. The rate of events shows a ~10% seasonal modulation and ~2% diurnal one. We find that the observed behaviour is explained by a model including the effects associated with the variations of pressure and density. The former affects the longitudinal development of air showers while the latter influences the Moliere radius and hence the lateral distribution of the shower particles. The model is validated with full simulations of extensive air showers using atmospheric profiles measured at the site of the Pierre Auger Observatory.Comment: 24 pages, 9 figures, accepted for publication in Astroparticle Physic